Reproduction Abstracts

Transforming growth factor beta (TGFβ) can induce The Warburg-effect, or aerobic glycolysis, in tumorigenesis. Energy-rich lactate, a by-product of glycolysis, ‘feeds’ tumour cells and increases apoptosis resistance, angiogenesis, and invasion, fuelling tumour progression and metastasis. As TGFβ is increased in the peritoneal fluid of women with endometriosis, we asked, is there a Warburg-like effect at play in endometriosis.Peritonea...

Introduction: Ectopic pregnancy is unique to humans and a leading cause of maternal morbidity/mortality however the etiology remains unknown. Leukemia inhibitory factor (LIF) has roles in extravillous-trophoblast adhesion/invasion and is expressed in ectopic pregnancy. We hypothesised that LIF facilitates blastocyst adhesion/invasion in the fallopian tube (FT), contributing to ectopic pregnancy. LIF blockade could serve as a treatment strategy.Methods: W...